Few people equipped to combat coronavirus on their own: Study

Image : The Week

A study published in the scientific journal ‘Nature Research’ has revealed that few people exposed to the novel coronavirus (Sars-CoV-2) may have an immune system prepared to combat it.

Here are five components of the story:

  • For this study, scientists examined Memory T cells induced by previous pathogens. These cells can ascertain the clinical severity of infections to some extent. Responses of these T cells to structural and non-structural regions in Covid-19 convalescents led researchers to demonstrate the presence of CD4 and CD8 T cells in recognizing multiple regions of the NP protein.
  • “We then showed that SARS-recovered patients still possess long-lasting memory T cells reactive to SARS-NP 17 years after the 2003 outbreak, which displayed robust cross-reactivity to SARS-CoV-2 NP,” the study asserted.
  • The study adds that scientists unexpectedly discovered SARS-CoV-2 specific T cells in people with no history of SARS, Covid-19 or contact with patients contaminated by these. The study says, “SARS-CoV-2 T cells in uninfected donors exhibited a different pattern of immunodominance, frequently targeting the ORF-1-coded proteins NSP7 and 13 as well as the NP structural protein.”
  • “Infection with beta coronaviruses induces multispecific and long-lasting T cell immunity to the structural protein NP,” the study concludes.
  • Authors, Nina Le Bert and Anthony T Tan point out that understanding how pre-existing NP- and ORF-1-specific T cells present in the general population impact vulnerability and pathogenesis of Covid-19 is of paramount importance for the management of the ongoing pandemic.

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Edit Desk

Author: Edit Desk

Karvaan India is an online journal of politics, culture, heritage, monuments and people. We initiate conversation around the following themes with an intent to question traditional mindsets, popular discourses and initiate meaningful debates around it.
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